ABSTRACT
Background: The current Covid-19 pandemic is not over. Everyone still needs to do Covid-19 prevention behavior. One of them is children. Children need special ways to understand how to prevent Covid-19 easily. Storytelling is an alternative to convey advice to children, introducing children to moral and social values. This study aimed was to determine the effect of storytelling on Covid-19 prevention behavior in school-age children. Methods: This type of research used quantitative research using the pre-experimental method one-group pretest-posttest design. The sample of this research was 37 students 3rd grade of Madrasah Diniyyah. Storytelling has been done using the corona storybook. The Covid-19 prevention behaviors that were observed were wearing masks, washing hands, maintaining distance, and avoiding crowds. Behavior has been observed before and after given storytelling. an instrument to determine the behavior of preventing Covid-19 using an observation sheet which includes wearing masks properly, washing hands properly, using hand sanitizer, not crowding with friends, and sitting apart while studying. Result: The results showed that Covid-19 prevention behavior in school-age children before storytelling showed most of the negative behavior (66.7%), and after being given storytelling, most of them showed positive behavior (86.7%). There is an effect of storytelling on Covid-19 prevention behavior in school-age children with a p-value of 0.000. Conclusion: Storytelling can be used as a way to change Covid-19 prevention behavior in school-age children
ABSTRACT
Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases and several types of cancer in the last two decades. Their promise can be attributed to their safety profiles, high potency, and ability to be rapidly and affordably manufactured. Now, many RNA-based vaccines are being evaluated in clinical trials as prophylactic and therapeutic vaccines. However, until recently, their development has been limited by their instability and inefficient in vivo transfection. The nanodelivery system plays a dual function in RNA-based vaccination by acting as a carrier system and as an adjuvant. That is due to its similarity to microorganisms structurally and size-wise; the nanodelivery system can augment the response by the immune system via simulating the natural infection process. Nanodelivery systems allow non-invasive mucosal administration, targeted immune cell delivery, and controlled delivery, reducing the need for multiple administrations. They also allow co-encapsulating with immunostimulators to improve the overall adjuvant capacity. The aim of this review is to discuss the recent developments and applications of biodegradable nanodelivery systems that improve RNA-based vaccine delivery and enhance the immunological response against targeted diseases.